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brain tumor
drink more than 3 alcohol-containing drinks per day
drug abuse or addiction
head injury
kidney disease or problems going to the bathroom
liver disease
lung disease, asthma, or breathing problems
seizures or epilepsy
an unusual or allergic reaction to tramadol, codeine, other medicines, foods, dyes, or preservatives
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Special warnings about Ultram

If you have stomach problems such as an ulcer, make sure your doctor is aware of them. Ultram may hide the symptoms, making them difficult to diagnose and treat.

Ultram can cause mental and physical addiction. If you've ever had a problem with narcotic painkillers such as Percocet, Demerol, or morphine, you should avoid Ultram. Withdrawal symptoms may occur if you stop taking Ultram abruptly. Such symptoms include anxiety, sweating, insomnia, pain, nausea, tremor, diarrhea, and respiratory problems. A gradual decrease in dosage will help prevent these symptoms.

Do not take more than the recommended dose of Ultram, since larger doses have been known to cause seizures, especially if you have epilepsy or are taking medications that also increase the risk of seizures. Among such medications are almost all antidepressant drugs, plus narcotics and major tranquilizers such as Loxitane and Stelazine.

If you have liver or kidney disease, be sure your doctor knows about it. Your dosage may have to be reduced.

Before you have any kind of surgery, make sure the doctor knows you are taking Ultram.

If you have any kind of breathing problem, use Ultram with caution or take a different kind of painkiller. Ultram can impair respiration, especially if taken with alcohol.

If you have experienced a head injury, consult your doctor before taking Ultram. The medication's effects may be stronger and could hide warning signs of serious trouble.


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п»їWhat is this medicine?

TRAMADOL is a pain reliever. It is used to treat moderate to severe pain in adults.
What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
brain tumor
drink more than 3 alcohol-containing drinks per day
drug abuse or addiction
head injury
kidney disease or problems going to the bathroom
liver disease
lung disease, asthma, or breathing problems
seizures or epilepsy
an unusual or allergic reaction to tramadol, codeine, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding

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Use Ultram as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Ultram by mouth with or without food.
If you miss a dose of Ultram and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Ultram .
Important safety information:
Ultram may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Ultram with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Ultram ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
Ultram may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect. To prevent it, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of this effect.
Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
Tell your doctor or dentist that you take Ultram before you receive any medical or dental care, emergency care, or surgery.
Serotonin syndrome is a possibly fatal syndrome that can be caused by Ultram . Your risk may be greater if you take Ultram with certain other medicines (eg, "triptans," MAOIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
Use Ultram with caution in the ELDERLY; they may be more sensitive to its effects, especially constipation, weakness or tiredness, severe lightheadedness, and indigestion.
Ultram should not be used in CHILDREN younger than 16 years old; safety and effectiveness in these children have not been confirmed.
PREGNANCY and BREAST-FEEDING: Ultram has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ultram while you are pregnant. Ultram is found in breast milk. Do not breast-feed while taking Ultram .

When used for long periods of time or at high doses, Ultram may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Ultram stops working well. Do not take more than prescribed.

Some people who use Ultram for a long time without a break may develop a physical need to continue taking it. This is known as physical DEPENDENCE. If you suddenly stop taking Ultram , you may experience WITHDRAWAL symptoms, including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.


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Does Ultram show in urine tests?
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In rare cases, Avapro can cause a severe drop in blood pressure. The problem is more likely if your body's supply of water has been depleted by dialysis treatments or high doses of diuretics. Symptoms include light-headedness, dizziness, and faintness, and are more likely when you first start taking the drug. Call your doctor if they occur. You may need to have your dose adjusted.

If you have kidney disease, Avapro must be used with caution.
Possible food and drug interactions when taking Avapro

The chances of an interaction with Avapro are low. Check with your doctor, however, before combining it with tolbutamide.
Special information if you are pregnant or breastfeeding

Avapro can cause injury or even death to the unborn child when used during the last 6 months of pregnancy. As soon as you learn you're pregnant, stop taking Avapro and call your doctor.

It is not known whether Avapro appears in breast milk, but because of potential risks to the newborn, it's considered best to avoid using the drug while breastfeeding. You and your doctor should decide whether to give up nursing or discontinue Avapro.
Recommended dosage for Avapro

ADULTS

High Blood Pressure

The recommended starting dose of Avapro is 150 milligrams once a day. If your blood pressure remains elevated, your dose will be gradually increased to 300 milligrams once a day.

If you are being treated with hemodialysis or high doses of diuretics, you'll be started at a lower dose of 75 milligrams once a day.

Kidney Damage from Type 2 Diabetes

The usual dose is 300 milligrams once a day.

CHILDREN

For children under 6, safety and effectiveness have not been established. For children 6 to 12 years old, the typical starting dose is 75 milligrams once a day. If blood pressure is still too high, the dose may be increased to 150 milligrams once a day. Children 13 to 16 years old are usually given the adult dosage.

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п»їPossible side effects of Avapro :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

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Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the hands, eyes, mouth, face, lips, or tongue; hoarseness); change in the amount of urine produced; chest pain; dark urine; difficulty swallowing; fast, slow, or irregular heartbeat; muscle pain or cramps; severe or persistent stomach pain (with or without nausea or vomiting); severe or persistent tiredness; symptoms of low blood pressure (eg, fainting, severe dizziness, lightheadedness); vision changes; yellowing of the skin or eyes.



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п»їIRBESARTAN (Systemic)


Some commonly used brand names are:

In the U.S.—
Avapro
Category
Antihypertensive
Description

Irbesartan (ir-be-SAR-tan) belongs to the class of medicines called angiotensin II inhibitor antihypertensives. It is used to treat high blood pressure (hypertension).

High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure also may increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Irbesartan works by blocking the action of a substance in the body that causes blood vessels to tighten. As a result, irbesartan relaxes blood vessels. This lowers blood pressure.

This medicine is available only with your doctor's prescription, in the following dosage form(s):
Oral
Tablets (U.S.)
Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For irbesartan, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to irbesartan. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Use of irbesartan during pregnancy, especially during the second and third trimesters (after the first 3 months), can cause low blood pressure, severe kidney failure, or even death in the newborn. Therefore, it is important that you check with your doctor immediately if you think that you may have become pregnant . Be sure that you have discussed this with your doctor before taking this medicine.

Breast-feeding—It is not known whether irbesartan passes into breast milk. However, irbesartan passes into the milk of lactating rats. Because this medicine may cause serious side effects, breast-feeding is generally not recommended while you are taking it.

Children—This medicine has been tested in children over 6 years of age and has not been shown to cause different side effects or problems than it does in adults.

Older adults—This medicine has been tested in patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults. However, blood levels of irbesartan may be increased in the elderly and elderly patients may be more sensitive to the effects of irbesartan.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking irbesartan, it is especially important that your health care professional know if you are taking any of the following:
Diuretics (water pills)—Effects on blood pressure may be increased

Other medical problems—The presence of other medical problems may affect the use of irbesartan. Make sure you tell your doctor if you have any other medical problems, especially:
Congestive heart failure, severe—Lowering of blood pressure by irbesartan may make this condition worse
Dehydration—Blood pressure-lowering effects of irbesartan may be increased.
Kidney disease—Effects of irbesartan may be increased because of slower removal of medicine from the body.


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